Early effects of uranyl nitrate on respiration and K+ transport in rabbit proximal tubule
نویسندگان
چکیده
منابع مشابه
Rabbit Proximal Convoluted Tubule Transport
This in vitro microperfusion study examined the effects of growth hormone and insulin-like growth factor I (IGF-I) on proximal convoluted tubule (PC1) transport. Tubules were perfused with an ultrafiltrate-like solution and bathed in a serumlike albumin solution. Neither a physiologic (5 X 10-10 M), nor a pharmacologic (5 X 10jM) dose of growth hormone had an effect on PCT phosphate or bicarbon...
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The kidney has the highest abundance of cytochrome P-450 of all extrahepatic organs. Within the kidney, the highest concentration of cytochrome P-450 is found in the proximal tubule. Whether 20- or 19(S)-hydroxyeicosatetraenoic acid (HETE), the major P-450 metabolites of arachidonic acid in the proximal tubule, affect transport in this segment has not been previously investigated. We examined t...
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Angiotensin-converting enzyme (ACE) inhibitors such as captopril, which block ANG II formation, are commonly used for treatment of hypertension. There is substantial evidence that the proximal tubule (PT) is a primary target site for captopril but the molecular mechanisms for its action in PT are not well defined. The aim of this study was to determine the physiological and molecular changes in...
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Proximal straight tubules from rabbit kidneys were perfused in vitro in order to study transport of bicarbonate. Total CO2 content was measured in perfused and collected tubule fluid, using microcalorimetry. When the initial perfusate and bath contained 25 mM bicarbonate, the concentration of total CO2 decreased in the collected tubule fluid, indicating net reabsorption of bicarbonate. When the...
متن کاملDevelopmental Changes in Rabbit Proximal Straight Tubule
The early proximal tubule preferentially reabsorbs organic solutes and bicarbonate over chloride ions resulting in a luminal fluid with a higher chloride concentration than that in blood. From this late proximal tubular fluid, half of NaCl reabsorption by the adult proximal tubule is active and transcellular and half is passive and paracellular. The purpose of the present in vitro microperfusio...
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ژورنال
عنوان ژورنال: Kidney International
سال: 1989
ISSN: 0085-2538
DOI: 10.1038/ki.1989.156